Regional lymphadenectomy vs. extended lymphadenectomy for hilar cholangiocarcinoma (Relay-HC trial): study protocol for a prospective, multicenter, randomized controlled trial

Abstract Ice Bucket Background The prognostic benefits and safety of extended lymphadenectomy for hilar cholangiocarcinoma remain uncertain.The available evidence is still insufficient concerning its retrospective aspect.The aim of this study is to explore the clinical effect and safety of extended lymphadenectomy compared to regional lymphadenecto

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A Two-Piece Derivative of a Group I Intron RNA as a Platform for Designing Self-Assembling RNA Templates to Promote Peptide Ligation

Multicomponent RNA-peptide complexes are attractive from the viewpoint of artificial design of functional biomacromolecular systems.We have Smoothing Treatment developed self-folding and self-assembling RNAs that serve as templates to assist chemical ligation between two reactive peptides with RNA-binding capabilities.The design principle of previo

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